Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC030
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-02 09:36
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3/4+1/4+1/2+1/4 caps Madopar a 125mg 2 uvece old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 25 individuals with a value less than 0.6 were subsequently diagnosed with PD. That is, 59.52% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.6 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 40, 'TN': 29, 'TP': 2, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 19.468
timePerCircleCoV 0.51606
timePerCircleSlope -0.137786
meanError 1.33514
tremorFreq 5.95703
tremorRelPower 32.7796
tremorGyroAmpMean 0.0229472
tremorGyroAmpSlope 0.000553617
tremorGyroAmpCoV 0.454644
tremorCoordAmpMean 0.0477368
tremorCoordAmpSlope 0.00975438
tremorCoordAmpCoV 1.93755
tremorAccAmpMean 0.0252333
tremorAccAmpSlope 0.000604931
tremorAccAmpCoV 0.340555
tremorPcRelVar 0.608225
tremorPcX -0.96727
tremorPcY -0.253748

Circle Segment 1

Duration 35.68 s, Accuracy Estimate 1.725 (lower is better)

Circle Segment 2

Duration 40.32 s, Accuracy Estimate 2.018 (lower is better)

Circle Segment 3

Duration 17.8 s, Accuracy Estimate 0.761 (lower is better)

Circle Segment 4

Duration 15.88 s, Accuracy Estimate 1.008 (lower is better)

Circle Segment 5

Duration 16.76 s, Accuracy Estimate 0.986 (lower is better)

Circle Segment 6

Duration 16.48 s, Accuracy Estimate 1.264 (lower is better)

Circle Segment 7

Duration 14.84 s, Accuracy Estimate 1.233 (lower is better)

Circle Segment 8

Duration 13.76 s, Accuracy Estimate 1.389 (lower is better)

Circle Segment 9

Duration 12.04 s, Accuracy Estimate 1.226 (lower is better)

Circle Segment 10

Duration 11.12 s, Accuracy Estimate 1.742 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 27.972
timePerSpiralCoV 0.22343
timePerSpiralSlope -0.0567581
meanError 1.9855
tremorFreq 6.25
tremorRelPower 36.3365
tremorGyroAmpMean 0.0187244
tremorGyroAmpSlope 0.000450579
tremorGyroAmpCoV 0.358536
tremorCoordAmpMean 0.0374051
tremorCoordAmpSlope 0.00145011
tremorCoordAmpCoV 0.320666
tremorAccAmpMean 0.0771931
tremorAccAmpSlope 0.000205726
tremorAccAmpCoV 0.0719689
tremorPcRelVar 0.635855
tremorPcX 0.836717
tremorPcY -0.547636

Spiral Segment 1

Duration 43.8 s, Accuracy Estimate 2.161 (lower is better)

Spiral Segment 2

Duration 31.12 s, Accuracy Estimate 1.825 (lower is better)

Spiral Segment 3

Duration 28.04 s, Accuracy Estimate 1.706 (lower is better)

Spiral Segment 4

Duration 26.08 s, Accuracy Estimate 1.914 (lower is better)

Spiral Segment 5

Duration 24.6 s, Accuracy Estimate 2.037 (lower is better)

Spiral Segment 6

Duration 28.76 s, Accuracy Estimate 1.996 (lower is better)

Spiral Segment 7

Duration 28.24 s, Accuracy Estimate 1.842 (lower is better)

Spiral Segment 8

Duration 23.84 s, Accuracy Estimate 2.155 (lower is better)

Spiral Segment 9

Duration 23.36 s, Accuracy Estimate 1.968 (lower is better)

Spiral Segment 10

Duration 21.88 s, Accuracy Estimate 2.251 (lower is better)

Elel

eDurationMean 0.560357
eDurationStd 0.22232
eDurationStdnorm 0.396747
eDurationMedian 0.53
eDurationQuartdelta 0.15
eDurationQuartdeltanorm 0.283019
eDurationKurt 15.8547
eDurationTrenddiff -0.03
eDurationTrendratio 0.944954
eWidthMean 5.30957
eWidthStd 1.1677
eWidthStdnorm 0.219924
eWidthMedian 5.265
eWidthQuartdelta 1.404
eWidthQuartdeltanorm 0.266667
eWidthKurt 3.25182
eWidthTrenddiff -0.585
eWidthTrendratio 0.9
eHeightMean 10.0369
eHeightStd 2.4239
eHeightStdnorm 0.241498
eHeightMedian 10.062
eHeightQuartdelta 3.276
eHeightQuartdeltanorm 0.325581
eHeightKurt 2.25519
eHeightTrenddiff -3.276
eHeightTrendratio 0.717172
eAspectMean 0.542315
eAspectStd 0.116599
eAspectStdnorm 0.215002
eAspectMedian 0.532292
eAspectQuartdelta 0.132377
eAspectQuartdeltanorm 0.248693
eAspectKurt 2.4848
eAspectTrenddiff 0.0776794
eAspectTrendratio 1.16255
eSlantMean 0.0302497
eSlantStd 0.152285
eSlantStdnorm 5.03425
eSlantMedian 0.0292817
eSlantQuartdelta 0.239361
eSlantQuartdeltanorm 8.17442
eSlantKurt 2.14842
eSlantTrenddiff 0.03436
eRtopMean 0.692042
eRtopStd 0.137662
eRtopStdnorm 0.198922
eRtopMedian 0.690598
eRtopQuartdelta 0.202797
eRtopQuartdeltanorm 0.293654
eRtopKurt 2.69319
eRtopTrenddiff 0.0386973
eRbotMean 0.671078
eRbotStd 0.219282
eRbotStdnorm 0.32676
eRbotMedian 0.666667
eRbotQuartdelta 0.320513
eRbotQuartdeltanorm 0.480769
eRbotKurt 2.50516
eRbotTrenddiff 0.0555556
eRrightMean 0.807003
eRrightStd 0.0862471
eRrightStdnorm 0.106873
eRrightMedian 0.821601
eRrightQuartdelta 0.132813
eRrightQuartdeltanorm 0.161651
eRrightKurt 3.01007
eRrightTrenddiff 0.0311355
eRleftMean 0.389824
eRleftStd 0.12961
eRleftStdnorm 0.332482
eRleftMedian 0.380858
eRleftQuartdelta 0.16014
eRleftQuartdeltanorm 0.420472
eRleftKurt 2.91157
eRleftTrenddiff -0.0693681
lDurationMean 0.84875
lDurationStd 0.216077
lDurationStdnorm 0.254582
lDurationMedian 0.785
lDurationQuartdelta 0.2075
lDurationQuartdeltanorm 0.264331
lDurationKurt 3.4855
lDurationTrenddiff -0.035
lDurationTrendratio 0.956923
lWidthMean 6.474
lWidthStd 1.76777
lWidthStdnorm 0.273057
lWidthMedian 6.084
lWidthQuartdelta 2.3985
lWidthQuartdeltanorm 0.394231
lWidthKurt 2.7399
lWidthTrenddiff -1.755
lWidthTrendratio 0.758065
lHeightMean 24.154
lHeightStd 6.98355
lHeightStdnorm 0.289126
lHeightMedian 23.283
lHeightQuartdelta 8.5995
lHeightQuartdeltanorm 0.369347
lHeightKurt 3.63357
lHeightTrenddiff -8.5995
lHeightTrendratio 0.691176
lAspectMean 0.274996
lAspectStd 0.058224
lAspectStdnorm 0.211727
lAspectMedian 0.258692
lAspectQuartdelta 0.0872852
lAspectQuartdeltanorm 0.33741
lAspectKurt 2.93455
lAspectTrenddiff 0.0491458
lAspectTrendratio 1.19913
lSlantMean -0.0347966
lSlantStd 0.100902
lSlantStdnorm -2.89976
lSlantMedian -0.0554052
lSlantQuartdelta 0.124791
lSlantQuartdeltanorm -2.25233
lSlantKurt 3.23292
lSlantTrenddiff -0.02322
lRtopMean 0.616897
lRtopStd 0.164959
lRtopStdnorm 0.267401
lRtopMedian 0.597503
lRtopQuartdelta 0.248058
lRtopQuartdeltanorm 0.415158
lRtopKurt 2.3563
lRtopTrenddiff 0.138687
lRbotMean 0.788288
lRbotStd 0.293019
lRbotStdnorm 0.371715
lRbotMedian 0.804898
lRbotQuartdelta 0.375953
lRbotQuartdeltanorm 0.467082
lRbotKurt 4.07582
lRbotTrenddiff 0.12436
lRrightMean 0.787335
lRrightStd 0.0726659
lRrightStdnorm 0.0922934
lRrightMedian 0.786642
lRrightQuartdelta 0.120244
lRrightQuartdeltanorm 0.152857
lRrightKurt 2.02753
lRrightTrenddiff 0.0154778
lRleftMean 0.474927
lRleftStd 0.216208
lRleftStdnorm 0.455244
lRleftMedian 0.503738
lRleftQuartdelta 0.376129
lRleftQuartdeltanorm 0.746675
lRleftKurt 1.79125
lRleftTrenddiff -0.17884

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

FITTS Short Modified

meanTouchScore 0.900202
sumTouchScores 14.4032
meanMovementTime 1.06367
numTouches 16
undershootPercentage 0
overshootPercentage 12.5

FITTS Long Modified

meanTouchScore 0.937328
sumTouchScores 12.1853
meanMovementTime 1.42167
numTouches 13
undershootPercentage 0
overshootPercentage 7.69231

ZigZag

numZigzags 5
timePerZigzagMean 59.296
timePerZigzagCoV 0.0832003
timePerZigzagSlope 0.0101187
meanError 1.81349
tremorFreq 5.85938
tremorRelPower 26.3596
tremorGyroAmpMean 0.0313507
tremorGyroAmpSlope -5.21089e-05
tremorGyroAmpCoV 0.457065
tremorCoordAmpMean 0.0414139
tremorCoordAmpSlope 0.000792792
tremorCoordAmpCoV 0.382115
tremorAccAmpMean 0.0558487
tremorAccAmpSlope 0.000347905
tremorAccAmpCoV 0.203222
tremorPcRelVar 0.69315
tremorPcX -0.694024
tremorPcY 0.719952

ZigZag Segment 1

Duration 60.76 s, Accuracy Estimate 2.026 (lower is better)

ZigZag Segment 2

Duration 59.08 s, Accuracy Estimate 2.02 (lower is better)

ZigZag Segment 3

Duration 56.64 s, Accuracy Estimate 2.075 (lower is better)

ZigZag Segment 4

Duration 53.4 s, Accuracy Estimate 1.765 (lower is better)

ZigZag Segment 5

Duration 66.6 s, Accuracy Estimate 1.182 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 21.784
timePerZigzagCoV 0.16727
timePerZigzagSlope -0.0991553
zigzagHeightMean 76.1899
zigzagHeightCoV 0.0514363
zigzagHeightSlope 0.00514589
meanError 0.0397549
tremorFreq 5.76172
tremorRelPower 40.2667
tremorGyroAmpMean 0.0468644
tremorGyroAmpSlope 0.00020253
tremorGyroAmpCoV 0.377478
tremorCoordAmpMean 0.0868136
tremorCoordAmpSlope 0.00340553
tremorCoordAmpCoV 0.388341
tremorAccAmpMean 0.108311
tremorAccAmpSlope 0.000814569
tremorAccAmpCoV 0.133988
tremorPcRelVar 0.73446
tremorPcX 0.397154
tremorPcY -0.917752

ZigZag Offset Segment 1

Duration 25.28 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 2

Duration 25.0 s, Accuracy Estimate 0.034 (lower is better)

ZigZag Offset Segment 3

Duration 22.76 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 4

Duration 17.8 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 5

Duration 18.08 s, Accuracy Estimate 0.037 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.69}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.6}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.12625787910798492}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9244164608497754}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}